Director | Center for Chemical Dynamics in Living Cells
Jaeyoung Sung (성재영)
Director of Center for Chemical Dynamics in Living Cells
Room # 417, Surim Science Hall(Building # 104)
Department of Chemistry
College of Natural Sciences
84 Heukseok-Ro, Dongjak-gu,
Seoul, 06974, Republic of Korea
Fax : +82-2-825-4736
Email : firstname.lastname@example.org
● Seoul National University, Doctor of Philosophy in Physical Chemistry (March 1993~August 1997)
Ph. D. Dissertation Title: Many-particle effects on the kinetics of diffusion-influenced reactions.
Supervisor: Prof. Sangyoub Lee
● Seoul National University, Master of Science in Physical Chemistry (March 1991 ~ February 1993)
● Seoul National University, Bachelor of Science in Chemistry (March 1987~ February 1991)
● 2015.12 ~ Present: Director, Creative Research Initiative Center for Chemical Dynamics in Living Cells, Chung-Ang University-National Research Foundation of Korea
● 2014.03 ~ 2016.02: Department Head, Department of Chemistry, Chung-Ang University
● 2013.07: Organizer, STATPHYS 25 Satellite meetings “Stochastic transport & reaction processes in condensed media”
● 2011.07 ~ 2012.05: Visiting Professor, Department of Chemistry, Massachusetts Institute of Technology
● 2012.06: Visiting Scholar, Center for the Physics of Living Cells, University of Illinois at Urbana-Champaign
● 2012.03 ~ Present: Professor of Chemistry, Chung-Ang University
● 2007.03 ~ 2012.02: Associate Professor, Department of Chemistry, Chung-Ang University
● 2004.03 ~ 2007.02: Assistant Professor, Department of Chemistry, Chung-Ang University
● 2000.09 ~ 2004.02: Postdoctoral Associate in Professor Bob Silbey’s group in Chemistry department at Massachusetts Institute of Technology
● 1998.09 ~ 2000.08: Postdoctoral research fellow, Institute of Basic Science, Korea University.
● 1997.09 ~ 1998.08: Special research fellow, Institute of Basic Science and Research, Seoul National University.
Single molecule dynamics & spectroscopy
Statistical thermodynamics of non-extensive systems
Molecular transport and reaction in disordered media
Solvation effects in chemical dynamics and equilibrium
Awards and Honors
● Fellowship, (Massachusetts Institute of Technology, 2011~2012)
● Fellowship for Distinguished Postdoctoral Scholars (Korea Science and Engineering Foundation, 2000~2001)
● Fellowship for Distinguished Postdoctoral Scholars in Korea (Korea Research Foundation, 1998~1999)
● Fellowship for a Distinguished Research (Institute of Basic Science and Research, Seoul National University 1997~1998)
● Scholarship for Distinguished Ph. D. Candidates (Seoam Scholarship Foundation, 1995~1997)
● Fellowship for Young Researchers (Korea Research Foundation, 1993)
● Appreciation Plaque from the President of Chung-Ang University in 2016 as recognition of outstanding contribution to the academic competitiveness of Chung-Ang University.
● Creative Research Initiative Center Project Grant, National Research Foundation of Korea. (December, 2015)
● National Laboratory Project Grant, National Research Foundation of Korea (November, 2015)
● The Kook-Joe Shin Academic Excellence Prize from the Korean Chemical Society (2015 with the first awardee honor)
● Appreciation Plaque from the President of Korean Chemical Society in recognition for contributing to the advancement of the Korean Chemical Society as a Steering Committee Member of Academic Affairs (2014).
● Distinguished Ph. D. Dissertation Award (Department of Chemistry, Seoul National University, 1997)
● A3-NIMS Joint Workshop on Interdisciplinary Research, May 2017 (KAIST)
● Winter Q-Bio 2017 @ Kauai-Grand Hyatt, February 2017
● Seminar at IBS Center for Soft and Living Matter, January 2017 (UNIST)
● KIAS Workshop on Stochasticity and Fluctuations in Small Systems, December 2017 (POSTECH)
● Seminar, Asia Pacific Center for Theoretical Physics (APCTP), October 2016
● 2016 Chemistry Seminar, Korea University
● STATPHYS 26, Lyon, July 2016
● 2016 Chemistry Seminar, Yonsei University
● 2016 Workshop on Stochasticity and Fluctuations in Small Systems, POSCO International Center
● 2016 Joint Symposium, the Institute of Basic Science-Korean Chemical Society
● 2016 Seminar, BROAD Institute at Cambridge (hosted by Professor James J. Collins, Massachusetts Institute of Technology)
● Honorary talk as the first recipient of the Kook-Joe Shin Academic Excellence Award, Korean Chemical Society April Meeting, in 2015
● KAIST Young Chemist Symposium, 2015
● Chemistry Seminar, UNIST, 2014
● Chemistry Seminar, POSTECH, 2014
● Chemistry Seminar, Kangwon National University, 2014
● Physical Chemistry Symposium, Korean Chemical Society Meeting, 2014
● Chemistry Seminar, Seoul National University, 2013
● “Stochastic transport & reaction processes in condensed media”, STATPHYS 25 Satellite meetings, 2013
● Physical Chemistry Seminar, Boston University, 2012
● Single Molecule Dynamics, Telluride Conference, 2011
● Seminar, Biomedical Engineering Department at Nanyang Technology University, 2011
● 2016 ~ Present, Review Board, the National Research Foundation of Korea
● 2016, Secretary of General Affairs, Physical Chemistry Division of the Korean Chemical Society
● 2014, Steering Committee of Academic Affairs, the Korean Chemical Society
● 2014, Member, General Board of Publishing Committee, the Korean Chemical Society
● 2014, Science Committee Member, the Korean Chemical Society
● 2014 ~ 2015, Committee member, Authentication Affairs of Chemistry Majors at the Korean Chemical Society
● 2013 ~ 2014, Representative of the Korean Chemical Society, the Korean Union of Chemical Science and Technology Societies
● 2013, Steering Committee of Public Affairs, the Korean Chemical Society
● 2007 ~ 2013, Information Committee Member, the Korean Chemical Society
Representative Academic Achievements
1. My research group and I proposed a new model and chemical kinetics optimized for a quantitative description of intracellular networks [Phys. Rev. X 5, 031014 (2015)]. Taking this new approach, we presented simple, analytic results that could provide a unified quantitative explanation of protein level variability observed across a number of different systems, which is a remarkable breakthrough in the field. This work presents a new paradigm of quantitative investigation into the stochastic behaviours of biological networks.
2. We developed a new experimental and analysis method for quantitative investigation into the propagation of the chemical fluctuation through intracellular networks. We demonstrated the usefulness of this method by investigating the propagation of RNA polymerase concentration variation into protein expression noise [Nature Communications 5, 4761 (2014)].
3. Unlike most fluids, liquid helium does not obey the Gibbs fluctuation-compressibility relation, which was noted more than 60 years ago. However, a clear explanation of this deviation or the correct fluctuation-compressibility relation for the quantum liquid had continued to elude researchers. However, in Phys. Rev. E 89, 062131 (2014), we solved the long-standing problem in quantum statistical mechanics. We presented the fluctuation-compressibility relation, which is valid for any grand canonical system including quantum liquids, discovering the fundamental relationship between particle exchange symmetry and thermodynamic extensivity.
4. My group has developed a new chemical kinetics for non-Poisson, renewal reaction processes and applied it to enzyme reactions, and has discovered the quantitative relationship between the fluctuation in the enzymatic turnover times and the substrate concentration. [Jung, Yang, & Sung, “Novel Chemical Kinetics for a Single Enzyme Reaction: Relationship between Substrate Concentration and the Second Moment of Enzyme Reaction Time”, J. Phys. Chem. B 114, 9840 (2010)]. This theory could provide an unprecedented quantitative explanation of the experimentally measured randomness parameter in the single enzyme turnover times reported in Nat. Chem. Biol. 2, 87 (2006). [Yang, Jung, Cao, Silbey, & Sung, “Quantitative Interpretation of the Randomness in Single Enzyme Turnover Times”, Biophys. J. 101, 519 (2011)].
5. With Professor K. M. Ok and co-workers, I presented a quantitative explanation of the anomalous isotherm of a large 1D channel thorium organic framework [K. M. Ok, J. Sung et al., J. Am. Chem. Soc. 130, 3762 (2008)] (Cited by 78).
6. Professor Bob Silbey and I have presented the relationship between the counting statistics of single molecule reaction events and the reaction dynamics of a single molecule with a fluctuating rate coefficient [Sung & Silbey, Chem. Phys. Letters 415, 10 (2005)] (Cited by 24).
7. I was the first to prove that Jarzynski’s equality, also known as the work-fluctuation theorem, does not always hold true [Sung, Phys. Rev. E76 012101 (2007)], and I also provided the application range of the latter equation in [Sung, Phys. Rev. E 77, 042101 (2008)], which are both unprecedented achievements. This work was initially motivated by Professor Bob Silbey, though he preferred not to appear as an author. After publication, these papers were neglected for several years and did not earn the attention they were due from experts in the field. However, I am happy to note that recently they are finally gaining traction and garnering support in the academic community!
8. I discovered the exact dynamics of a continuous time random walker in the presence of a boundary in [Sung & Silbey, Phys. Rev. Lett. 91, 160601 (2003)]. Before this work, the dynamics of a continuous time random walker in the presence of a boundary had been an open question for many years. (Cited by 26)
9. With Professor Bob Silbey and Dr. Eli Barkai, now a professor at Bar-Ilan University, at Massachusetts Institute of Technology, I developed the fractional dynamics approach to diffusion-assisted reactions in disordered media [Sung et al., J. Chem. Phys. 116, 2338 (2002)] (Cited by 66).
10. Under the guidance of Professor Bob Silbey, I developed a general theory of four wave mixing spectroscopy for a multi-level system, which provided an unprecedented quantitative interpretation of vibrational photon echo phenomena. [Sung & Silbey, J. Chem. Phys. 115, 9266 (2001) (Cited by 82); Demirdöven et al., Phys. Rev. Lett. 89, 237401 (2002)]. The initial motivation for this work was provided by Professor Andrei Tokmakoff at Massachusetts Institute of Technology and Professor Minhaeng Cho at Korea University.
11. Under the supervision of Professor Sangyoub Lee at Seoul National University, I formulated a theory of kinetics that accurately describes the reversible association reactions in liquids, published in [Sung & Lee, J. Chem. Phys. 111, 796 (1999)] (Cited by 52). Before this work, the relaxation kinetics of the reversible association reaction could not be quantitatively explained by any of the existing theories- an open problem for more than a decade. The prediction of our theory was found to be in perfect agreement with the accurate simulation results. This theory was quite influential at the time and remains the most accurate theory to account for this phenomenon to this day. I subsequently provided the relationship among various theories for reversible diffusion-influenced reactions in [Sung & Lee, J. Chem. Phys. 111, 10159 (1999)] (Cited by 52); [Sung & Lee, J. Chem. Phys. 112, 2128 (2000)] (Cited by 43).
45. Seong Jun Park, Gil-Suk Yang, Sanggeun Song, Phillip M. Kim, Sangwoon Yoon, Ji-Hyun Kim, and Jaeyoung Sung*, "The Chemical Fluctuation Theorem governing gene expression", Nature Communications 9, article 297, (2018).
44. In-Chun Jeong, Sanggeun Song, Daehyun Kim, Seong Jun Park, Ji-Hyun Kim, and Jaeyoung Sung*, "Comment on 'Nonrenewal statistics in the catalytic activity of enzyme molecules at mesoscopic concentrations'", Physical Review Letters, (2017).
43. Seong Jun Park, Sanggeun Song, In-Chun Jeong, Hye Ran Koh, Ji-Hyun Kim, and Jaeyoung Sung*, "Nonclassical Kinetics of Clonal yet Heterogeneous Enzymes", J. Phys. Chem. Lett., 8 (13), 3152-3158 (2017).
42. Yu Rim Lim, Ji-Hyun Kim, Seong Jun Park, Gil-Suk Yang, Sanggeun Song, Suk-Kyu Chang, Nam Ki Lee, and Jaeyoung Sung*, “Quantitative understanding of probabilistic behavior of living cells operated by vibrant reaction networks”, Phys. Rev. X 5, 031014 (2015). https://doi.org/10.1103/PhysRevX.5.031014
41. Sora Yang, Seunghyeon Kim, Yu Rim Lim, Cheolhee Kim, Hyeong Jeon Ah, Ji-Hyun Kim, Jaeyoung Sung*, and Nam Ki Lee*, “Contribution of RNA polymerase concentration variation to protein expression noise”, Nat. Commun. 5, 4761 (2014). https://doi.org/10.1038/ncomms5761
40. Yu Rim Lim, Seong Jun Park, Sanggeun Song, Gil-Suk Yang, Young-Gui Yoon Ji-Hyun Kim and Jaeyoung Sung*, “Exchange symmetry, fluctuation-compressibility relation, and thermodynamic potentials of quantum liquids”, Phys. Rev. E89, 062131 (2014) https://doi.org/10.1103/PhysRevE.89.062131
39. Yu Rim Lim, Seong Jun Park, Bo Jung Park, Jianshu Cao, Robert J. Silbey, and Jaeyoung Sung*, “Reaction event counting statistics of Biopolymer reaction system with dynamic heterogeneity”, J. Chem. Theor. Comp. 8, 1415 (2012). https://doi.org/10.1021/ct200785q
38. Seongeun Yang, Jianshu Cao, Robert J. Silbey, Jaeyoung Sung*, “Quantitative interpretation of the randomness in single enzyme turnover times”, Biophysical Journal 101, 519 (2011). http://doi.org/10.1016/j.bpj.2011.06.022
37. Bo Jung Park, Won Jung, and Jaeyoung Sung*, “Unified theory for a receptor system with a distributed binding affinity to substrates”, Chem. Phys. 384, 36 (2011). http://doi.org/10.1016/j.chemphys.2011.04.031
36. Sangyoub Lee, Chang Yun Son, Jaeyoung Sung, and Song-Ho chong, (Communication) “Propagator for diffusive dynamics of an interacting molecular pair”, J. Chem. Phys. 134, 121102 (2011). http://doi.org/10.1063/1.3565476
35. Won Jung, seongeun Yang, and Jaeyoung Sung*, “Novel Chemical Kinetics for a Single Enzyme Reaction: Relationship between Substrate Concentration and the Second Moment of Enzyme Reaction Time”, J. Phys. Chem. B 114, 9840 (2010) https://doi.org/10.1021/jp1001868
34. Yu Rim Lim, Won Jung, Je Hyun Bae, Bo Jung Park, Joonkyung Jang, and Jaeyoung Sung*, “Excess Grand Potential for a System under an External Field: Effects of External Field Driven Nonextensivity”, J. Phys. Chem. B 113 (Letter) 7982 (2009). https://doi.org/10.1021/jp900629d
33. S. Kim, W. Shim, H. Seo, J.H. Bae, J. Sung, S.H. Choi, W.K. Moon, G. Lee, B. Lee, and S.W. Kim, “Bandgap engineered reverse type-I CdTe/InP/ZnS core-shell nanocrystals for the near-Infrared”, Chem. Comm. 1267 (2009). https://dx.doi.org/10.1039/B820864F
32. Je Hyun Bae, Yu Rim Lim, Won Jung, Robert J. Silbey, and Jaeyoung Sung*, “Practical Model for Imperfect Conductometric Molecular Wire Sensors”, Anal. Chem. 81, 578 (2009). https://doi.org/10.1021/ac801715x
31. Jaeyoung Sung*, “Application range of Jarzynski’s equation for boundary switching processes”, Phys. Rev. E 77, 042101 (2008). https://doi.org/10.1103/PhysRevE.77.042101
30. Ji-Hyun Kim, Woojin Lee, Jaeyoung Sung, and Sangyoub Lee, “Excluded Volume Effects on the Intrachain Reaction Kinetics”, J. Phys. Chem. B 112, 6250 (2008). https://doi.org/10.1021/jp076426i
29. Je Hyun Bae, Yu Rim Lim, and Jaeyoung Sung*, “Statistical Mechanics of Molecular Adsorption: Effects of Adsorbate Interaction on Isothersm”, Langmuir 24, 2569 (2008). https://doi.org/10.1021/la703372t
28. Kang Min Ok, Jaeyoung Sung, Robert M. J. Jacobs, and Dermot O’Hare, “TOF-2: A Large 1D Channel Thorium Organic Framework”, J. Am. Chem. Soc. 130, 3762, (2008). https://doi.org/10.1021/ja800395q
27. Changsung Eun, Ji-Hyun Kim, Jinuk Lee, Je Hyun Bae, Yu Rim Lim, Sangyoub Lee, and Jaeyoung Sung*, “Mean First Passage Time for the Contact between the Ends of a Chain Polymer”, J. Phys. Chem. B 111, 10468 (2007). https://doi.org/10.1021/jp071640s
26. Ji-Hyun Kim, Dahn, Huh, Jinuk Lee, Sangyoub Lee, Jaeyoung Sung “Subdiffusion-assisted reaction kinetics in disordered media”, J. Phys.: Condens. Matter 19, 065116 (2007). http://stacks.iop.org/JPhysCM/19/065116
25. Joonkyung Jang, Jaeyoung Sung, and George C. Schatz, “Influence of Surface Roughness on the Pull-Off Force in Atomic Force Microscopy”, J. Phys. Chem. C 111, 4648 (2007). https://doi.org/10.1021/jp066667a
24. Jaeyoung Sung*, “Theoretical test of Jarzynski’s equality for reversible volume-switching processes of an ideal gas system”, Phys. Rev. E 76, 012101 (2007). https://doi.org/10.1103/PhysRevE.76.012101
23. Jaeyoung Sung, and Robert J. Silbey, “Quantitative Relationship between analyte concentration and amplified signal intensity of a molecular wire sensor”, Anal. Chem. 77, 6169 (2005). https://doi.org/10.1021/ac050659t
22. Jaeyoung Sung, and Robert J. Silbey, “Counting statistics of single molecule reaction events and reaction dynamics of a single molecule”, Chem. Phys. Lett. 415, 10 (2005). http://doi.org/10.1016/j.cplett.2005.08.057
21. Jaeyoung Sung, and Robert J. Silbey, “Exact dynamics of continuous time random walker in the presence of boundary: beyond phenomenological boundary condition approach”, Phys. Rev. Lett. 91, 160601 (2003). https://doi.org/10.1103/PhysRevLett.91.160601
20. Jaeyoung Sung, and Robert J. Silbey, “Optical Four wave mixing spectroscopy for a multi level system coupled to Brownian oscillators” J. Chem. Phys. 118, 2443 (2003). http://dx.doi.org/10.1063/1.1534103
19. Jaeyoung Sung, Jinwook Lee, and Sangyoub Lee, “Theory of intrapolymer excimer-formation kinetics”, J. Chem. Phys. 118, 414 (2003). http://dx.doi.org/10.1063/1.1525801
18. Jaeyoung Sung, Eli Barkai, Robert J. Silbey, and Sangyoub Lee, “Fractional Dynamics Approach to the Diffusion-Assisted Reaction in Disordered Media” J. Chem. Phys. 116, p2338 (2002). -This article is also selected for publication in 2002 Feb. 1st Issue of ‘virtual journal of Biological Physics Research” http://dx.doi.org/10.1063/1.1448294
17. Jaeyoung Sung and Robert J. Silbey, “Four Wave Mixing Spectroscopy for a Multi-level System”, J. Chem. Phys. 115, p9266 (2001). http://dx.doi.org/10.1063/1.1413979
16. Jaeyoung Sung, Hwangseo Park and Sangyoub Lee, “Green’s Function Approach to the Nonclassical Reaction Kinetics in Fractal Media”, Phys. Rev. Lett. 84, p2463 (2001). https://doi.org/10.1103/PhysRevLett.86.2463
15. Jaeyoung Sung, Robert J. Silbey, and Minhaeng Cho, “Effects of temperature on the nonlinear response function for two-dimensional vibrational spectroscopy”, J. Chem. Phys. 115, p1422 (2001). http://dx.doi.org/10.1063/1.1379751
14. Laura J. Kaufman, Jiyoung Heo, Graham R. Fleming, Jaeyoung Sung and Minhaeng Cho, "Fifth-order electronically non-resonant Raman scattering: two-dimensional Fourier deconvolution" Chem. Phys. 266, 251 (2001). http://doi.org/10.1016/S0301-0104(01)00251-8
13. Jaeyoung Sung and Sangyoub Lee, “Intrachain fluorescence quenching in a flexible polymer: A theory for frequency-domain fluorometric experiments”, J. Chem. Phys. 115, p9050 (2001). http://dx.doi.org/10.1063/1.1411992
12. Jaeyoung Sung and Minhaeng Cho, “Calculation of the two-dimensional vibrational response function”, J. Chem. Phys. 113, 7072 (2000). http://dx.doi.org/10.1063/1.1312276
11. Minhaeng Cho, David A. Blank, Jaeyoung Sung, Kisam Park, Sangjoon Hahn, and Graham R. Fleming, “Intrinsic cascading contributions to the fifth- and seventh-order electronically off-resonant Raman spectroscopies”, J. Chem. Phys. 112, p 2082 (2000). http://dx.doi.org/10.1063/1.480777
10. Juhyeok Lee, Jaeyoung Sung, and Sangyoub Lee, “Excluded volume effects on the diffusion-influenced reaction: The many-particle kernel approach”, J. Chem. Phys. 113, 8686 (2000). http://dx.doi.org/10.1063/1.1318738
9. Jaeyoung Sung and Sangyoub Lee, “Relations among the Modern Theories of Diffusion-Influenced Reaction: 2. Reduced distribution Function theory vs. Modified Integral Encounter Theory”, J. Chem. Phys. 112, p 2128 (2000). http://dx.doi.org/10.1063/1.480780
8. Jaeyoung Sung and Sangyoub Lee, “Relations among the Modern Theories of Diffusion-Influenced Reaction: 1. Reduced distribution Function theory vs. Memory Function Theory of Yang, Lee, and Shin”, J. Chem. Phys. 111, p10159 (1999). http://dx.doi.org/10.1063/1.480366
7. Jaeyoung Sung, Joonhwa Chi, and Sangyoub Lee, “Nonequilibrium Distribution Function Theory of Diffusion-Influenced Reversible Energy-Transfer Reactions”, J. Chem. Phys. 111, p804 (1999). http://dx.doi.org/10.1063/1.479198
6. Jaeyoung Sung and Sangyoub Lee, “Nonequilibrium Distribution Function Formalism for Diffusion-Influenced Bimolecular Reactions: Beyond the Superposition Approximation”, J. Chem. Phys. 111, p796 (1999). http://dx.doi.org/10.1063/1.479367
5. Jaeyoung Sung, Kook Joe Shin, and Sangyoub Lee, “Relaxation Kinetics of Diffusion-Influenced Reactions of the Type Perturbed by Flash Photolysis”, J. Chem. Phys. 109, p9101 (1998). http://dx.doi.org/10.1063/1.477466
4. Jaeyoung Sung, Kook Joe Shin, and Sangyoub Lee, “Many-Particle Effects on the Relaxation Kinetics of Fast Reversible Reactions of the Type”, J. Chem. Phys. 107, p9418 (1997). http://dx.doi.org/10.1063/1.475239
3. Jaeyoung Sung, Kook Joe Shin, and Sangyoub Lee, “Effect of Light Intensity on the Fluorescence Quenching Kinetics Probed by Frequency-Domain Fluorometry”, J. Chem. Phys. 101, p7241 (1994). http://dx.doi.org/10.1063/1.468281
2. Jaeyoung Sung, Kook Joe Shin, and Sangyoub Lee, “Effects of Static Quenching and Light Pulse Intensity on the Time-Dependent Fluorescence Quenching Kinetics”, Chem. Phys. 179, p23 (1994). https://doi.org/10.1016/0301-0104(93)E0339-W
1. Jaeyoung Sung, Kook Joe Shin, and Sangyoub Lee, “Theory of Diffusion-Influenced Fluorescence Quenching: Effects of Static Quenching On the Stern-Volmer Curve”, Chem. Phys. 167, p17 (1992). https://doi.org/10.1016/0301-0104(92)80020-V