- Nonclassical Chemical Kinetics for Description of Chemical Fluctuation in a Dynamically Heterogeneous Biological System
강진규Views: 176, 2016.03.04 16:07:16
- Bulletin of Korean Chemical Society, Vol. 33, No. 3, 2012, 963-970
Yu Rim Lim, Seong Jun Park, Sangyoub Lee,‡ and Jaeyoung Sung*
Department of Chemistry, Chung-Ang University Seoul 156-756, Korea. *E-mail: firstname.lastname@example.org
‡Department of Chemistry, Seoul National University, Seoul 151-742, Korea
We review novel chemical kinetics proposed for quantitative description of fluctuations in reaction times and in the number of product molecules in a heterogeneous biological system, and discuss quantitative interpretation of randomness parameter data in enzymatic turnover times of β-galactosidase. We discuss generalization of renewal theory for description of chemical fluctuation in product level in a multistep biopolymer reaction occurring in a dynamically heterogeneous environment. New stochastic simulation results are presented for the chemical fluctuation of a dynamically heterogeneous reaction system, which clearly show the effects of the initial state distribution on the chemical fluctuation. Our stochastic simulation results are found to be in good agreement with predictions of the analytic results obtained from the generalized master equation.